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For me :

Tha Playah and Tommyknocker - The Easy Way

i have it as ringtone and since the release i have it as ringtone and i am hearing it every fucking time on repeat when i walk home drunken at night (1:52 long sample) and the melody DOES NOT get even a bit boring.

and even if it's my ringtone i still love to hear it everytime. so, best mainstream melody ever for me

Critical Mass - Burning Love ( The Viper Remix)
still the best mainstream melody ever created.
that vipe and energy at the build up and climax damn

Ophidian - Butterfly VIP
D-Passion - Violate
Ophidian & Ruffneck - So many Sacrifices
Enzyme X - Dissonant Poetry (Second Verse by Ruffneck & Ophidian)
Nosferatu - The Underground Stream
Lenny Dee - The Dreamer (Promo Remix)
The Masochist - Killing Scum (Promo Remix)

Oh man that's way too difficult to choose

But so far:

Ophidian - The Middle Children
Nosferatu - The Underground Stream

Hard Creation - Bastard/Asshole
Hard Creation - I Will Have That Power
Tha Playah - Fuck The Fame
The Masochist - Killing Scum
Paul Elstak - Hardcore Hooligan
G-Town Madness Vs The Viper - Here It Comes
Paul Elstak- I Had To Kill Alot Of People (Nosferatu Remix)

Amnesys - Mainstream Nitro
Outblast & Angerfist - Dominator 2009
Nosferatu & Tha Playah - Fade To Nothing

that's really hard to choose and it there are different kind of melody's ... I have to think about it before I answer but it's definitely something from the Millenium Era and Tha Playah, Nosferatu etc.

Forgotten Moments Remix anyone?

This thread lacks 'Link - Headnod Delivery'. Probably the best melody ever! Such an awesome track And how about 'Korsakoff - My Empty Bottle' or 'Angels Entity - Daylight'?

Vicious wrote:Tha Playah - Fuck Tha Fame

Not only one of the best melodies, but overall one of the best tracks ever!

Future Shokk wrote:Ophidian - The Middle Children
Nosferatu - The Underground Stream

Both are alltime favorites

Nekasrof wrote:Amnesys - Mainstream Nitro
Nosferatu & Tha Playah - Fade To Nothing

Pure gold indeed

SCH wrote:Ophidian - Butterfly VIP
D-Passion - Violate
Ophidian & Ruffneck - So many Sacrifices

Vicious wrote:G-Town Madness Vs The Viper - Here It Comes
Paul Elstak- I Had To Kill Alot Of People (Nosferatu Remix)

Again epic ones!

Some others, which are not mentioned yet (with some Early HC and Industrial as well):

Angels Of Darkness - Cold As Ice
Meagashira - Lost In Music
Chaosbringer - End Of Days
Nosferatu - Have It Your Way
Endymion - Rock The Part-E
Endymion - Bio
DJ Kristof & Bad Boy - Seasons Of Mist (Nosferatu Remix)
Hellsystem - Bad Days
Hellsystem - Another World
D-Dr!ve - Versus
Weapon X - Get The Fuck Out My Way
Prowler - Reality
Ophidian - Angel
Ruffneck & Ophidian - The Real
DJ D - Samara
Hellsystem - Without Fear
Dance Overdose - Wake Up To The Overdose (The Marc Smith Notorious Mix)
DJ Sim - Loud As Fuck (54321 Mix)
DJ Sim - Cartoons In Progress
Lenny Dee - Forgotten Moments (also the Ophidian remix)
The Blaster - Face Of the Pain (DJ D Remix)
Evil Entity - Escape From Reality
Amnesys - I Justified
Hard Creation - We Won't Have It
Miro - Purple Moon
Masters Of Ceremony - Put It To Music
The Viper - Intellectual Killer (Nosferatu & Endymion remix)
D-Passion - The End Of Eternity
D-Passion - Good Memories
Unknown - Fuck The Rumours
Unknown - 95% Against Me
Promo - Escape From The Hostile
Promo - Insp-Her-Ation
Promo - Rising Out Of The Dark
Osiris - Remember The Name
T-Junction - The Rise and Fall
Angerfist - Take U Back
Tha Playah - Bling Bling
Tommyknocker - Learn From The Pain
Niel & Kristof – They Need What We Have
Proto X - Hectik

To be continued

Nosferatu - Strenght

Rest of my favorites are already listed!